Episode 81: Cracking the druggable genome with Dietrich Stephan, Founder and CEO of NeuBase Therapeutics
June 29th, 2022 | 42 mins 38 secs
This week Patrick is joined by Dietrich Stephan, Founder and CEO of NeuBase Therapeutics.
EP 80: Rare disease genomics and the 'near-coding' genome with Nicky Whiffin, Group Leader at the Wellcome Centre for Human Genetics
June 15th, 2022 | 24 mins 39 secs
From decoding the genetics of rare disease using computational methods, to understanding the non-coding and 'near-coding' genome, this week Patrick is joined by Nicky Whiffin, Group Leader at the Wellcome Centre for Human Genetics and Sir Henry Dale Fellow at the University of Oxford.
EP 79: The Unknown Causes of Kidney Disease Project with Michael Spigler, Vice President of Patient Support and Education at American Kidney Fund
June 1st, 2022 | 30 mins 24 secs
In this week’s episode Patrick is joined by Michael Spigler, Vice President of Patient Support and Education at American Kidney Fund.
EP78: From datasets to front-line healthcare; polygenic risk scores and genomic prediction with Prof Sir Peter Donnelly, CEO of Genomics PLC
May 18th, 2022 | 45 mins 49 secs
This week Patrick is joined by Sir Peter Donnelly, CEO of Genomics PLC and Professor of Statistical Science at the University of Oxford.
EP77: The journey to novel gene therapies for hearing loss and balance disorders with Laurence Reid, CEO at Decibel Therapeutics
May 4th, 2022 | 36 mins 30 secs
This week’s guest is Laurence Reid, CEO at Decibel Therapeutics.
EP 76: The UK Biobank Whole Genome Sequencing Project: building the future of genomics research with Dr Mark Effingham, Dr Kári Stefánsson and Professor Marylyn Ritchie
April 20th, 2022 | 41 mins 16 secs
This week Patrick is joined by three pioneering guests united by one ground-breaking project: the UK BioBank’s Whole Genome Sequencing Project.
EP 75: Participant engagement in genomics research, with Nathalie Kingston, Director of the NIHR BioResource
April 6th, 2022 | 40 mins 58 secs
This week’s guest is Nathalie Kingston, Director of the NIHR BioResource.
December 19th, 2021 | 52 mins 40 secs
In the last episode of the year, Patrick joins forces with the host of the Personalized Medicine Podcast, Sasha Yagensky, to discuss six of the biggest and most exciting breakthroughs in genetics research in 2021.
EP73: Ochre Bio: Building an in-silico liver model and addressing the impact and challenges of developing new treatments
November 24th, 2021 | 37 mins 11 secs
In this week’s episode Patrick speaks to Quin Wills and Jack O’ Meara, Co-Founders of Ochre Bio, about their founding story, why in-silico discoveries could be the road to faster and lower cost liver therapeutics, and the need for prioritising preventative measures against disease as the average human lifetime gets longer.
EP72: The DecodeME team on the challenges facing myalgic encephalomyelitis and chronic fatigue syndrome patients and the future of personalised treatments
November 10th, 2021 | 32 mins 25 secs
In this week’s episode Patrick speaks to Sonya Chowdhury, Chris Ponting and Andy Devereux-Cooke from the DecodeME project, the world’s largest genetic myalgic encephalomyelitis (ME) and chronic fatigue syndrome study
EP 71: Chief Medical Officer at LyGenesis, Professor Paulo Fontes, on the future of organ transplants
October 29th, 2021 | 36 mins 34 secs
This week’s guest, Paulo Fontes, is a Professor of Surgery and Chief Medical Officer at LyGenesis, an organ regeneration technology platform with a current focus on liver regeneration for patients with end stage liver disease.
EP70: The University of Oxford's Professor Cecilia Lindgren: understanding complex disease through big data and team science
October 14th, 2021 | 40 mins 5 secs
In this week’s episode Patrick speaks to Director of the Big Data Institute at University of Oxford, Professor Cecilia Lindgren, about her biggest eureka moment, the power of collaboration and consortiums across academia and industry to grow genetic sample sizes and accelerate research, and the importance of best practice standards to enable genetic research to scale successfully.
EP69: Chief Scientific Officer at Parkinson's Foundation, Dr James Beck, and Dr Ignacio Mata, Professor at the Cleveland Clinic, on the genetics of Parkinson’s disease and the future of precision treatments
September 24th, 2021 | 40 mins 41 secs
What is the role of genetics in Parkinson’s disease?
EP68: Dr Patrick Short features on GIANT’s Healthy Innovators Podcast and discusses the path to creating a successful startup in genomic medicine
September 1st, 2021 | 36 mins 53 secs
In this special episode we’re sharing Patrick’s guest appearance on GIANT’s Healthy Innovators Podcast.
EP67: Dr Anna Lewis from the Edmond J. Safra Center for Ethics at Harvard, on the biggest ethical questions in DNA sequencing and editing
August 18th, 2021 | 36 mins 17 secs
As more and more people get their DNA sequenced, through health care initiatives, biobanks and direct-to-consumer testing, an array of ethical questions arise.
EP 66: Professor David Strain, Senior Clinical Lecturer at the University of Exeter Medical School, on the emergence of Long COVID, its impact and how research is vital for supporting patients
August 4th, 2021 | 46 mins
For many Long COVID patients the debilitating long-term symptoms they experience emerged after what, at first, appeared to be a mild COVID-19 infection